IQ Products/Complete standardized high quality kit for the diagnosis of HIT/IQP-396,IQ Products,,IQ Products,iqproducts,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：IQ Products/Complete standardized high quality kit for the diagnosis of HIT/IQP-396

产品编号：IQP-396

市场价：¥0.00

场地：美国(厂家直采)

产品分类：试剂盒>其它试剂盒>定量试剂盒>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：待定

品牌： IQ Products

公司：IQ Products

公司分类：

商品介绍

Information

IntroductionHeparin-inducedthrombocytopenia(HIT)isanacute,immune-mediatedprocessthatmayresultinlife-threateningthrombosis.HITiscausedbyplatelet-activating,heparin-dependentantibodies,whoformcomplexesofheparintogetherwitheitherplateletfactor-4(PF-4)(mostoftheclinicalcases),interleukin-8(IL-8)orneutrophil-activatingpeptide2(NAP-2).Detectionoftheseantibodiesisanimportantlaboratoryfunction.

Theantibodiesareinitiallyformedafter5ormoredayswhenapatienthasbeenonheparintherapy.Animmuneresponsetoaheparindosemaybeobservedwithinminutesorhoursifthepatienthashadpreviousexposuretoheparinandantibodiesarealreadycirculating.

ThediagnosisofHITisdifficultbecauseitssignsarenon-specificandduetotheabovementionedstructureitisveryimportanttolookforthepresenceandfunctionofthecomplexspecificantibodies.

DiagnosticsFordetectionofHITtwodifferentkindofassayscanbeused,theimmunologicalandfunctionalassay.Thefunctionalassaysreproducethein-vivopathophysiology,andhighlycorrelatewiththeclinicalpresentationofHIT.Thisisincontrasttotheimmune-detectionantigen(antigenemia)assays,whichmeasureantibodiesreactivetotheheparinplatelet-factor4(PF4)complexes.However,onlyafractionofpatientspositiveinthesetestsdevelopclinicalHIT.Ontheotherhand,pathogenicantibodiesmayalsoreactwithotherheparincomplexes,suchasheparin-interleukin-8,orheparin-neutrophilactivatingpeptide2,thus,notbeingdetectedbythoseassays.

AnimmunologicalassaycanbetheEnzyme-LinkedImmunosorbentAssay(ELISA)ortheGelTest(PaGIA),whichissimilartoELISA.Thedisadvantageofthesetestsisthefactthattheyarenon-functionalassays,theygivemorethan10%falsenegativeanda20%disagreementwithSRA.

AfunctionalassayistheSEROtonin-releaseassay(SRA),whichissensitiveandspecific, butnon-feasIBLebecauseoftheuseofrADIoisotypes.AnotherfunctionalassayistheAggregationAssaybutithasalowsensitivityandalongtimetoperform.

PrincipleoftheHITAlert™KitRecently,theAmericanCollegeofChestPhysicians(ACCP)haspostedupdatesonrecommendationsfortestingofHIT.ThisshouldfurtherincreasetheneedofhighperformancetestingforHIT.TheHITAlert™Kitissuchatest.

FortheHITAlert™Kitdonorplatelets(PRP)areused,whichareincubatedinthepresenceofpatientserumandinthepresenceorabsenceofheparin.WhenpathogenicantibodiesarepresenttheactivationofthedonorplateletsisshownusingaplateletactivationMarker.Byincubatingthesampleswithanantibodyagainstplateletsandtheactivationmarkerthisreactioncanbevisualizedusingflowcytometry.

Results

A	B	C

Figure:ResultsofHITAlert™Kit:(A)dotplotofPEpositiveplatelets,(B)negativepatient,(C)positivepatient.

品牌介绍

IQ Products

IQ products是一个全球性开发，制造以及供应的生物厂家。有着一系列高质量的抗体诊断产品。流式细胞仪是其专业的产品之一，其业务范围还包括ELISA，抗体和其他生物试剂等。

Since 1987 IQ Products developed many different diagnostic assays, like the Fetal Cell Count™ Kit. IQ Products is recognized for the development, manufacturing and registration of innovative kits in niche areas using antibody-based assays for reliable diagnostics. It is our mission to“Contribute to better healthcare by developing and providing smart, innovative and reliable diagnostics”.

In 2012 we decided to focus our Research & Development and portfolio extension on Women’s Health. This resulted in several patents and patent applications in the field of prognostic assays to determine the risk and pregnancy related disorders.It is our vision to be “A leading specialty diagnostics company in the field of Women’s Health” With a team of dedicated people IQ Products aims to contribute to better healthcare. IQ focuses on those products bringing innovative solutions to replace, improve or complement current diagnostics. In close collaboration with valued customers IQ is striving for the best solution for each situation. By working with leading scientists and listening to what the market would like to see IQ Products develops those antibody based specialty products that make a difference.

产品列表：

IQ Products	IQP-126F	Thymocytes	1.0 mL for 100 test
IQ Products	IQP-126P	Thymocytes	1.0 mL for 100 test
IQ Products	IQP-126R	Thymocytes	1.0 mL for 100 test
IQ Products	IQP-100F	T cells, E rosette rec, thymocytes, NK cells	1.0 mL for 100 test
IQ Products	IQP-100P	T cells, E rosette rec, thymocytes, NK cells	1.0 mL for 100 test
IQ Products	IQP-100R	T cells, E rosette rec, thymocytes, NK cells	1.0 mL for 100 test
IQ Products	IQP-519A	Thymocytes, mature T cells	1.0 mL for 100 test
IQ Products	IQP-519C	Thymocytes, mature T cells	1.0 mL for 100 test
IQ Products	IQP-519F	Thymocytes, mature T cells	1.0 mL for 100 test
IQ Products	IQP-519P	Thymocytes, mature T cells	1.0 mL for 100 test
IQ Products	IQP-519PC	Thymocytes, mature T cells	1.0 mL for 100 test
IQ Products	IQP-519PCC	Thymocytes, mature T cells	1.0 mL for 100 test
IQ Products	IQP-519R	Thymocytes, mature T cells	1.0 mL for 100 test
IQ Products	IQP-535A	T helper/inducer cells, monocytes, macrophages	1.0 mL for 100 test
IQ Products	IQP-535C	T helper/inducer cells, monocytes, macrophages	1.0 mL for 100 test
IQ Products	IQP-535F	T helper/inducer cells, monocytes, macrophages	1.0 mL for 100 test
IQ Products	IQP-535P	T helper/inducer cells, monocytes, macrophages	1.0 mL for 100 test
IQ Products	IQP-535PC	T helper/inducer cells, monocytes, macrophages	1.0 mL for 100 test
IQ Products	IQP-535PCC	T helper/inducer cells, monocytes, macrophages	1.0 mL for 100 test
IQ Products	IQP-535R	T helper/inducer cells, monocytes, macrophages	1.0 mL for 100 test
IQ Products	IQP-103F	Thymocytes, T cells, B cell subset	1.0 mL for 100 test
IQ Products	IQP-103P	Thymocytes, T cells, B cell subset	1.0 mL for 100 test